Walk into any supplement store and the one thing you’re guaranteed to see plastered all over the place are “Nitric Oxide boosters”.  Take this product and have “mind blowing pumps and vascularity”.  All of these supplements are based on primarily one ingredient – L-Arginine.   L-Arginine has been around the supplement industry forever, promising drastic results in vascularity and “the pump”.  Unfortunately we’ve all been had.  It has been proven that L-Arginine doesn’t promote nitric oxide synthesis, and can actually be harmful if used long term.

But I REALLY like my Pumps?!...

Enter Agmatine: The Next Generation Arginine! 

What exactly is Agmatine?  It is a byproduct of Arginine, essentially Agmatine is Arginine with the carboxylic acid removed.

The benefits of Agmatine are literally endless, and science is continually finding new applications for the use of Agmatine, not only in Bodybuilding and Fitness, but also in General Health and Longevity.

The bodybuilding and physical performance benefits of Agmatine are pretty dramatic, and noticed within a few doses of Agmatine. Those benefits include, but by no means are limited to:

• Improved body composition via improved insulin response
• Positive effects on LH and GH
• Anxiolytic effects potentially leading to the control of cortisol levels and fat loss
• Nitric oxide modulation
• Improved recovery
• Increased performance
• Increased endurance
• Decreased body fat

The health and longevity benefits of Agmatine are just as dramatic and important as the performance benefits you get, and are as follows:

• Agmatine acts as an analgesic and anti-inflammatory agent
• Antioxidant role

Agmatine HIGHLIGHTS:

• Improve body composition
• Improve the muscle pump
• Enhance nutrient delivery
• Antioxidant

References:

 J Nutr Biochem. 2008 Aug 15. [Epub ahead of print]
Liu TH, Wu CL, Chiang CW, Lo YW, Tseng HF, Chang CK.
No effect of short-term arginine supplementation on nitric oxide production, metabolism and performance in intermittent exercise in athletes.

Regunathan S, Feinstein DL, and Reis DJ. Anti-proliferative and anti-inflammatory actions of imidazoline agents. Are imidazoline receptors involved? Ann NY Acad Sci. 881: 410-419, 1999.

Gao, Y., et al. Agmatine: a novel vasodilator substance. Life Sciences. 57(8):PL83-86, 1995.

Kalra, S.P., et al. Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing in vivo. Neuroscience Letters. 194 (3): July 21, 1995; 165-168.

Raghavan SA, Dikshit M. Vascular regulation by the L-arginine metabolites, nitric oxide and agmatine. Pharmacol Res. 49(5):397-414. Review, 2004.

Regunathan S, Feinstein DL, and Reis DJ. Anti-proliferative and anti-inflammatory actions of imidazoline agents. Are imidazoline receptors involved? Ann NY Acad Sci. 881: 410-419, 1999.

Sener A, et al. Stimulus-secretion coupling of arginine-induced insulin release. Insulinotropic action of agmatine. Biochemical Pharmacology. January 15, 1989. 38(2):327-330, 1989.

Synergistic with:

Agmatine is a very versatile product.  It can be stacked with any muscle building stack we have.  In particular, it would stack well with Creatine for muscle fullness, as well as Glycobol for additional nutrient delivery benefits.

Directions:

As a dietary supplement, take 4 capsules 30 minutes exercise.